Plexus Worldwide has launched Creatine+, a ready-to-mix powder featuring 5 grams of micronized creatine monohydrate per serving, along with L-leucine to promote muscle protein synthesis and vitamin D3 to support strength, immune function, and bone health.

According to Michael Hartman, vice president of research and development, the new supplement is intended to support individuals beyond muscle strength, to include broader performance, cognitive function, and cellular energy benefits. “It’s an all-in-one for active lifestyles who want the whole youthful package,” he said.

Creatine+ is intended for any adult focused on longevity goals, the company reported. It is flavorless and free from artificial colors, sweeteners, or preservatives, and is third-party tested by Informed Choice.

“Plexus formulated this product due to feedback from our customers, and our in-house research and development team went above and beyond,” said Tarl Robinson, CEO and founder. “2026 is the year Plexus is doubling down on our microbiome expertise with accessible products that help anyone achieve their lifestyle, fitness, and weight management goals.”

In an interview with Nutraceuticals World, Hartman discussed the company’s selection of complementary ingredients alongside creatine to bolster cellular energy and cognitive support.

“The addition of L-leucine specifically targets the activation of muscle protein synthesis, a critical factor in maintaining physical resilience as consumers age. Vitamin D3 was selected to round out this formula, providing essential support for bone density and immune function,” elevating creatine from its performance enhancer positionings to “a foundational element for mental clarity and total longevity support,” he said.

The target consumer for this formula includes adults seeking to proactively manage healthy aging and maintain muscle; those requiring cognitive support for demanding daily schedules and stress; and those seeking a third-party verified supplement free from artificial additives, Hartman said.

“Creatine+ distinguishes itself in the longevity space through several high-value attributes that prioritize both efficacy and user experience,” he noted. “The formula uses micronized creatine and gamma-cyclodextrin to ensure the product dissolves effortlessly into any beverage, effectively addressing the common consumer complaint of ‘gritty’ textures. As a leader in microbiome-focused wellness, Plexus positions this product to work in tandem with its existing gut health systems, supporting overall lifestyle, fitness, and weight management goals. Furthermore, the flavorless formulation allows users to easily integrate the supplement into their existing daily routines without the addition of artificial colors or sweeteners.”