Zeus Hygia, an India- and Florida-based nutraceutical company, has launched Metaberine, a high-potency berberine extract developed using the company’s BioSolve extraction technology, which is an aqueous, eco-friendly process.

A pharmacokinetic study comparing a 200 mg dose of Metaberine versus a berberine extract powder found that the maximum concentration (Cmax) of Metaberine was 37 times greater than that of the berberine powder. Time to reach Cmax was 30 minutes for Metaberine, compared to 8 hours for the berberine powder. Additionally, the area under the curve showed that Metaberine was nine times more bioavailable than the berberine powder.

Further, Zeus Hygia reported that in a randomized, placebo-controlled, crossover trial, 36 participants took 200 mg of Metaberine for 14 days. Compared to placebo, the Metaberine group saw a 23% increase in GLP-1 secretion on average, an 8% reduction in fasting blood glucose, and a 14% decrease in post-prandial glucose spikes. A 2% reduction in LDL cholesterol was also observed.

Metaberine supports healthy metabolic function through several complementary pathways, the company reported, including: gut microbiome balance, AMPK activation, reduced hepatic glucose production, and improved mitochondrial function.

Another metaberine study is underway, evaluating the supplement at a 200 mg daily dose in 100 subjects, and is expected to be completed by the end of Q2 2026.

“Metaberine outperforms conventional berberine, as our studies demonstrate,” said Arunkanth Krishnakumar, PhD, co-founder and director of the company. “GLP-1 agonists have become prominent in the conversation about weight loss and blood sugar management, but these solutions often come with intense GI side effects and are cost-prohibitive for many. As a natural, safe, and clinically proven lowest dose alternative, Metaberine can be a reliable and affordable metabolic health-support intervention. Metaberine is acknowledged as the most effective and thoroughly researched metabolic support available at the lowest daily dosage. Several supplement formulations with Metaberine are prepared to launch in the U.S. market within the coming months.”