A clinical trial found that supplementation with Magtein, a branded magnesium L-threonate ingredient, was associated with improvements in measures of cognitive performance, memory, reaction time, cognitive age, and heart rate. The findings were published in Frontiers in Nutrition.

The study recruited 100 healthy adults between the ages of 18 and 45, with self-reported dissatisfied sleep. For six weeks, they supplemented with two grams of Magtein daily or a placebo.

Cognitive performance was measured by the NIH Cognitive Toolbox, while Oura rings were used to track sleep and provide data on heart rate and heart rate variability. Sleep quality was also measured through self-reporting questionnaires, and reaction time and hand-eye coordination were assessed with a digital aim trainer.

Participants in the Magtein group demonstrated:

• Improved overall cognitive performance
• Greater improvements in working and episodic memory
• A 7.5-year reduction in estimated brain cognitive aging
• Faster reaction time
• Reduced resting heart rate and increased heart rate variability
• Improvements in self-reported sleep quality

“While earlier studies have demonstrated that Magtein supports cognitive performance in older populations, this latest research confirms those benefits also extend to younger adults,” said Jennifer Gu, PhD, senior vice president of research and development at Magtein. “It also highlights additional positive outcomes related to cognitive function, sleep-related measures, and physiological markers of neurological and heart health, including improved heart rate variability, which is demonstrated for the first time. Together, these findings build on a growing body of research supporting Magtein and further strengthen the scientific foundation behind its broad cognitive and neurological benefits.”

“As we look ahead, additional ongoing and upcoming studies will continue to expand our understanding of Magtein and its benefits,” Gu continued. “The growing body of evidence supports its use in formulations designed to support healthy brain cognitive aging, stress resilience, and sleep.”