Researchers from nutraceutical retailer GNC recently published a new peer-reviewed article in Obesity Pillars highlighting supplements that may be suitable to support those who are taking GLP-1 receptor agonists, such as Ozempic or Wegovy.

The review addresses the potential for complementary supplements during GLP-1 therapy to support muscle health, nutrition, and overall wellness, including with ingredients such as multivitamins, protein supplements, creatine, HMB, antioxidants, fiber, and probiotics.

“Patients are increasingly turning to weight loss medications, yet little peer-reviewed guidance exists on how to integrate dietary supplements alongside GLP-1 treatment with diet and exercise,” said Brittany Johnson, PhD, lead author. “This paper helps close that gap by providing evidence-based data that can be applied from prior weight loss science, while paving the way for future research combining GLP-1 and supplement interventions.”

Key Findings

The publication summarizes the current scientific evidence surrounding supplement use, dosing protocols, and integration into clinical care with core recommendations. Their recommendations, based on the findings, included:

• Multivitamins and vitamin D to support nutrient status
• Omega-3s to support muscle and heart health
• Protein, creatine, and HMB to preserve lean body mass during weight loss
• Antioxidants and anti-inflammatory nutrients like curcumin, polyphenols, and CoQ10 to reduce oxidative stress and support a healthy inflammatory response
• Fiber and prebiotics to improve bowel regularity and mitigate gastrointestinal side effects
• Thermogenics such as caffeine and green tea to increase energy expenditure

Understanding GLP-1 RA Users’ Needs

GNC previously supported what it reports was the first study evaluating nutrient intake among GLP-1 receptor agonist users. Additionally, a follow-up study is currently underway to assess nutritional habits, body composition, and health outcomes before and during GLP-1 treatment.

Each study is led by GNC’s research team, which includes PhDs and registered dietitian nutritionists (RDNs), with the goal of translating evidence into guidance and product formulas.

“Our research directly informs how we design products and build our GLP-1 focused portfolio,” said Rachel Kreider, vice president of product innovation at GNC. “By understanding the unique needs of this growing population, we can deliver tailored nutrition solutions that are rooted in science and aligned with consumer health goals.”