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The strain thrives in low-oxygen environments and directly produces butyrate, supporting gut barrier integrity and immune function.
September 29, 2025
By: Mike Montemarano
Associate Editor, Nutraceuticals World
Designs for Health has launched Anaerostipes Probiotic, a supplement featuring Anaerostipes caccae CLB101, a strain that supports gut lining, digestion, and overall gut balance.
This probiotic strain is a direct producer of butyrate via microbial fermentation, which fuels the cell lining between the but and bloodstream and supports gut barrier integrity, which also improves immune function.
Anaerostipes thrives in the low-oxygen environment of the colon and can be negatively impacted by certain bowel conditions and other metabolic disorders. Anaerostipes caccae CLB101 can convert unwanted lactate into butyrate; undigested carbohydrates are fermented by bacteria into D-lactate which is metabolized poorly. The strain also cross-feeds other beneficial gut microbes and promotes microbial diversity.
Citing research by the International Food Information Council, interest in probiotics has never been higher, with 32% of consumers actively trying to consume probiotics, Designs for Health reported.
“Anaerostipes is not just another probiotic, it’s a leap forward in gut health innovation,” said David M. Brady, ND, chief medical officer at Designs for Health. “By reintroducing a keystone organism like Anaerostipes caccae CLB101, we’re able to influence the entire microbial environment in a way that supports barrier function, immune regulation, and metabolic signaling, the core pillars of long-term GI health.”
The probiotic is delivered in a once-daily capsule and serves as a clinical tool for functional and integrative health practitioners to support their patients with a range of GI concerns, supporting the gut lining, promoting a healthy inflammatory response, and restoring microbiome balance, Designs for Health reported.
“The launch of Anaerostipes reflects our unwavering commitment to advancing the science of nutrition and delivering real solutions that address the root causes of health challenges,” said Amardeep Kahlon, CEO at Designs for Health. “As a brand built on clinical integrity and innovation, we strive to equip practitioners with cutting-edge tools that improve patient outcomes and redefine what’s possible in functional medicine.”
“With its focus on innovative, science-backed ingredients and leadership role in the functional medicine space, Designs for Health was the obvious partner to commercialize the first dietary supplement containing our next-generation Anaerostipes caccae CLB101 ingredient,” said Ritu Shah, CEO of ClostraBio. “Designs for Health has the team and the experience required to educate both healthcare practitioners and consumers on the important role for both CLB101 and butyrate in gut health.”
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