Botanical Extract Supports Fat Loss: Study

Sirtmax, a patented extract of black ginger (Kaempferia parviflora) distributed by Maypro, may support fat/weight loss in overweight adults, a new study published in Frontiers in Nutrition found.

The study included 83 participants who were randomly assigned to receive either 50 mg of Sirtmax or a placebo daily, with changes to body fat mass, body weight, and BMI assessed from baseline to 12 weeks. Body composition was measured using dual-energy X-ray absorptiometry (DEXA) and computed tomography imaging was used to evaluate regional fat distribution.

According to the findings, participants who took Sirtmax experienced significant reductions in total body fat mass, subcutaneous fat, and visceral fat compared to placebo, along with significant improvements in body weight, BMI, waist circumference, and visceral-to-subcutaneous fat ratio.

“Participants maintained their typical diets and activity levels throughout the trial,” researchers noted. “For optimal results, combining Sirtmax with a higher-protein diet and resistance exercise may help maximize fat loss while preserving lean mass.”

Visceral fat reduction supports improved insulin sensitivity, reduced oxidative stress, and improved cardiometabolic risk, the authors noted, and Sirtmax has potential as a novel, natural approach to support body fat metabolism in overweight populations.

Prior clinical studies indicate that Sirtmax works by activating SIRT1, a protein enzyme that plays a role in metabolism, stress response, and aging, which inhibits glycation. This results in favorable impacts on fat production (adipogenesis) and the secretion of adiponectin, along with protective effects against oxidative stress, MayPro noted.

Sirtmax is the only black ginger product patented in the U.S. for its role in SIRT1 activation. This is due to the ingredient’s ability to deliver high quantities of compounds known as KPMF-8 and KPMF-10, which result in high activation of SIRT1, at levels approximately 5-times greater than resveratrol and 3-times greater than conventional black ginger extracts, noted Lauren Clardy, senior director of branded ingredients at MayPro.