Women’s healthcare company Bonafide Health, LLC has launched Noctera, a hormone-free dietary supplement designed to improve sleep quality and duration in women impacted by hormonal changes.

Sleep disturbances are among the most common challenges faced by women aged 40 to 64, which can be linked to the hormonal fluctuations experienced during the menopause transition. Noctera’s continuous-release formula is designed to help balance the body’s natural sleep signals, calm the mind to improve sleep quality, reduce sleep disturbances, and ultimately improve daytime energy.

Noctera contains four key ingredients:

• Magnesium Glycinate: Blocks the excitatory signal causing wakefulness
• GABA: Promotes relaxation and calms the mind, for better sleep
• L-theanine: Works with magnesium to block the excitatory signals in the brain and rebalance the sleep-wake cycle
• SAMe: Further promotes sleep regulation and rebalance

A randomized, double-blind, placebo-controlled trial demonstrated that Noctera significantly improves sleep quality in perimenopausal and postmenopausal women with moderate-to-severe sleep disturbances. The supplement demonstrated a favorable safety profile throughout the study, with no significant adverse effects reported, the company reported.

Key findings from this study include:

• 88% of women experiencing moderate-to-severe sleep issues experienced reduced sleep disturbances, moving to “within normal limits” within 3 weeks of using Noctera
• Women experienced an average increase in sleep duration of 40 minutes
• 89% of women found it easier to fall back asleep after waking in the night when taking Noctera consistently as directed
• Women also subsequently reported improvement in morning grogginess, ease of getting out of bed, restfulness, daytime sleepiness, and sleep satisfaction

“Estrogen plays a critical role in how our brain regulates temperature, sleep, and mood,” said Dr. Alyssa Dweck, MS, MD, FACOG, MSCP, Bonafide’s chief medical officer and co-author of the Noctera studies. “Declining estrogen levels during the menopause transition affect the balance of both GABA, a calming neurotransmitter in the brain and Glutamate, an excitatory one. This imbalance has direct effects on sleep, specifically associated with the frequent nocturnal awakenings and difficulty falling back asleep during this time of life.”