PLT Health Solutions, has launched a new ingredient designed to support joint structure, enhance joint strength, and deliver lasting, foundational support. Kinexa Joint Longevity Complex is a patented combination of standardized extracts of Haritaki (Terminalia chebula), Turmeric (Curcuma longa), and Indian Frankincense (Boswellia serrata).

The combination improves foundational joint structure for whole-organ integrity, enabling stronger knees for better joint stability, according to PLT. It also enhances cartilage matrix composition, improving cartilage thickness and shock-absorbing capacity.

Kinexa is supported by a randomized, double-blind placebo-controlled clinical study that included detailed assessments of joint structures. Results demonstrated impacts on the health and integrity of soft tissues, the synovial cavity, and the foundational bone beneath the cartilage, in addition to functional mobility and traditional subjective outcomes like WOMAC.

“To date, most clinical work in the joint health sector has focused on enhancing comfort,” said Jeremy Appleton, ND, director of medical and scientific affairs at PLT Health Solutions. “But joints aren’t just ‘pain sensors.’ They are load-bearing mechanical systems. This new study on Kinexa is revolutionary because we are impacting a much broader range of factors that contribute to joint health and mobility.”

“Comfort is how the joint feels today,” Appleton continued, “structure is what determines whether it keeps working years from now. Joint longevity is ultimately structural. When cartilage, meniscus, ligaments, and the foundation beneath the cartilage stay strong and resilient, the joint can absorb shock, distribute load evenly, and remain stable through everyday life, training, aging, and wear-and-tear.”

Study Details

In the recent clinical study, 100 subjects aged 40-75 with Grade II or III osteoarthritis received 200 mg/day of Kinexa or a matching placebo for six months. Assessments occurred at baseline, 1, 2, 4, and 6 months. Key outcomes included WOMAC, VAS, and Lequesne Functional Index (LFI) scores. Functional measures included isometric knee torque, a 6-minute walk test, and a Timed Get Up and Go test.

The study also incorporated advanced MRI imaging techniques, including quantitative and semi-quantitative measures of cartilage and whole-joint structural integrity, which includes ligaments, menisci, subchondral bone, and synovium. Biomarkers of inflammation and cartilage metabolism were also evaluated.

Results reported in study include:

• 24% improvement in knee strength
• 10% improvement in cartilage thickness
• 4.2% improvement in cartilage composition
• Greater than 26% improvement in joint functional capacity
• 60% improvement in joint comfort
• 49% reduction in joint stiffness
• Increased glycosaminoglycan concentration in cartilage
• Enhanced ligament, meniscus, synovial and subchondral bone health

Joint Health/Mobility Portfolio

Kinexa adds to PLT’s portfolio of clinically supported joint health ingredients. The company’s AprèsFlex 5-Day Joint Support is featured in many joint health brands in the U.S. and beyond. Backed by four clinical studies, AprèsFlex delivers fast, low-dose support for joint comfort and cartilage health.

Meanwhile, the company’s Dynagenix Muscle+Joint Formula is a low-dose Boswellia serrata extract in a neutral-tasting, water-soluble form, making it ideal for formulating into contemporary delivery systems. In 2025, PLT announced a new study on its Dynagenix that demonstrated that 40 mg/day of Dynagenix led to statistically significant improvements in joint comfort, stiffness, and function as early as 5 days after initial supplementation.

“Kinexa raises the bar because it evaluates the joint as a system, not just how it feels,” said Jennifer Murphy, head of innovation and clinical science for PLT. “In this clinical study, we saw significant improvements in multiple measures of joint structure alongside functional outcomes, supported by advanced imaging. That combination is rare in our category, and it opens the door for our customers to develop new products that may contribute to long-term mobility across different life stages. We are looking forward to engaging the health and wellness community on what joint longevity can mean when you measure the whole joint.”