Supplement brand Vital Nutrients announced the results of an unpublished clinical study, in which Cortisol Balance, a supplement featuring ashwagandha, B vitamins, magnesium, Boswellia, vegan omega-3, eleuthero extract, and copaiba extract, supported improvements in symptoms related to sleep, mood, and stress.

The randomized, double-blind, placebo-controlled study tested the supplement against a placebo in 499 healthy adults seeking support for anxiety and stress, over a six-week treatment period.

According to the company, Cortisol Balance improved feelings of anxiety, perceived stress, sleep disturbance, and mood compared to placebo. Up to 85% of respondents reported improvement in both the levels and frequency of anxiousness and stress.

“This study provides important evidence that a comprehensive, systems-based approach to stress management can help people better adapt to the pressures of daily life,” said John P. Troup, PhD, chief science and innovation officer for Blueroot Health, the parent company of Vital Nutrients. “By supporting cortisol balance and healthy adrenal function, we can help the body manage stress where it starts, not just mask the symptoms, and improve overall well-being without relying on single-ingredient solutions.”

Cortisol Balance was evaluated as a finished formula, rather than relying on data from isolated ingredients, in a large and diverse U.S. population, the company noted. According to Troup, the supplement’s blend of adaptogenic herbs and nutrients works synergistically to help the body recover, reset, and rebalance after stress, supporting the hypothalamic-pituitary-adrenal (HPA) axis, endocannabinoid system, and circadian rhythm.