Brightseed Launches Digestive Health Ingredient Bio Gut Core

Brightseed has developed and launched a new digestive health ingredient from its AI platform. Bio Gut Core is a proprietary blend of NCT and NFT, bioactive compounds found in dozens of natural plant sources like garlic and black pepper.

A new human clinical trial supports the efficacy of Bio Gut Core to strengthen gut barrier function and promote digestive wellness within 3 weeks, the company said. Some subjects saw benefits within one week of supplementation.

The human clinical study commissioned by Brightseed is currently under review and is anticipated to be published in a peer-review journal later this summer.

According to the company, the bioactives found in Bio Gut Core can activate HNF4⍺, a transcription factor shown to play a key role in gut barrier function and integrity. Therefore, HNF4⍺ agonists, NCT and NFT, have the potential to support a healthy gut barrier function.

“Not only are we introducing a novel, nature-derived ingredient to the $51 billion digestive market, with Bio Gut Core we’re delivering a next-level solution to provide relief for the tens of millions of Americans affected by debilitating digestive health conditions,” said Lee Chae, PhD, co-founder and CEO, Brightseed. “This gut health clinical data further validates the ability of Brightseed’s AI-driven discovery to meaningfully improve human health and quality of life. We have big plans from here.”

Brightseed will be sharing findings from this study and more about the benefits of this new product at this year’s American Society for Nutrition NUTRITION 2025 Conference on May 31, 2025 in a session titled, “From Side Stream to Mainstream: How AI Discovered Bioactives Are Revolutionizing Gut & Metabolic Health Benefits in Consumer Goods.”

“This study provides clinical proof that bioactives NCT and NFT significantly improve gut barrier function, delivering a much needed solution to health companies and consumers alike,” said Swati Kalgaonkar, head of medical and scientific affairs and clinical research at Brightseed. “Even more exciting than the clinical data from this study are the real-life experiences of study participants who have reported drastic improvements in quality of life and adverse symptom reduction. These kinds of outcomes are the reason Brightseed exists.”