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The plant-based bioactive is linked to mood and stress support benefits.
March 26, 2025
By: Mike Montemarano
Associate Editor, Nutraceuticals World
Nutrition21 has announced the launch of EverZen, a 6-MBOA functional ingredient sourced from corn, which is clinically supported to confer mood and stress support benefits.
The naturally-occurring plant bioactive is standardized to a specific concentration of 6-methoxy-2-benzoxazolinone (6-MBOA), which, in plants, protects them from stressors like insects, fungi, and bacteria as they grow. In humans, this bioactive is thought to promote a healthy stress response and play a role in mood support, Nutrition21 reported.
EverZen has been shown to help with the production of neurochemicals associated with a positive mood, and may promote the activity of brain receptors that promote relaxation, which stabilizes cortisol, also known as “the stress hormone.”
EverZen is the only mood and stress support ingredient standardized to contain 6-MBOA, reports Nutrition21, and its suggested dosage is 250 mg. It is suitable for capsules, tablets, gummies, chews, powders, and other products.
“EverZen offers supplement manufacturers a one-of-a-kind alternative to ingredients like ashwagandha and is the only mental well-being ingredient on the market that leverages the power of the 6-MBOA compound,” said Steve Rosenman, CEO of Everwell Health, parent company of Nutrition21. “Clinical studies on EverZen have demonstrated its ability to enhance mood and stabilize cortisol levels, helping consumers feel mentally balanced, resilient, and at ease. This latest addition to the Nutrition21 portfolio is our first plant-based extract ingredient, and it was critical that EverZen meet the rigorous scientific, quality, and performance standards that our branded ingredients are trusted for. We partnered with an expert in botanical ingredient discovery and development to bring this novel extract to market. We’re thrilled to introduce this one-of-a-kind ingredient that delivers powerful benefits for mental well-being.”
“Mood and stress supplements are in high demand,” said Jordan Miller, VP of Marketing at Nutrition21. “We believe the market is primed and ready for a new generation of mood and stress products that can deliver real results for consumers. Today’s consumers report feeling anxious and overwhelmed. In fact, our own proprietary consumer research revealed that mood and stress is a concern, and only 14% rated their mood/stress levels as good. While many have tried supplements to address this health area, there is a clear satisfaction gap in the market, with 39% stating they were not satisfied with the product’s effect. EverZen provides supplement brands a new option to help consumers support their mental and emotional well-being, is easy to formulate with, and offers a more neutral taste profile, compared to the bitterness common with ayurvedic herbs and botanicals.”
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